Cluster analysis reveals abnormal hippocampal neurometabolic profiles in young people with mood disorders

DF Hermens; SL Naismith; KM Chitty; RSC Lee; A Tickell; SL Duffy; C Paquola; D White; IB Hickie; J Lagopoulos

Journal article

Cluster analysis reveals abnormal hippocampal neurometabolic profiles in young people with mood disorders

DF Hermens, SL Naismith, KM Chitty, RSC Lee, A Tickell, SL Duffy, C Paquola, D White, IB Hickie, J Lagopoulos

European Neuropsychopharmacology | ELSEVIER SCIENCE BV | Published : 2015

DOI: 10.1016/j.euroneuro.2015.02.009

Abstract

While numerous studies have employed magnetic resonance spectroscopy (MRS) to determine in vivo neurometabolite levels associated with mood disorders the findings in both unipolar depression and bipolar disorder have been mixed. Data-driven studies may shed new light on this literature by identifying distinct subgroups of patients who may benefit from different treatment strategies. The objective of the present study was to utilize hierarchical cluster analysis in order to generate new hypotheses with respect to neurometabolic profiling of mood disorder. Participants were 165 young persons (18-30 yrs) with a mood disorder and 40 healthy controls. Neurometabolite levels were recorded via prot..

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University of Melbourne Researchers

Rico Lee Author

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Grants

Funding Acknowledgements

Funding for this study was provided by National Health & Medical Research Council (NHMRC) Program (No. 566529) and a Centres of Research Excellence (No. 1061043) grants. Dr Lee is supported by a NHMRC Centres of Research Excellence Grant (No. 1061043). A/Prof Naismith is supported by a NHMRC Clinical Research Fellowship (No. 402864), Dr Duffy is supported by a Centres of Research Excellence Grant (No. 1060992) and Prof Hickie is supported by a NHMRC Senior Principal Research Fellowship (No. 1046899). The funders had no further role in study design; in the collection, analysis and interpretation of data; in the writing of the report; and in the decision to submit the paper for publication.